Aging
Aging
Aging is a deteriorative process of the biological system that gradually loses regeneration ability whereas catabolic pathways take over. Free Radical Theory of Aging postulates that aging is caused by the accumulation of oxidatively degraded macromolecules results from reactive oxygen species (ROS) throughout the life span. Supplementation of antioxidants has been regarded beneficial to attenuate aging effects. However, recent research challenges this theory and even provides evidence that ROS stimulates the organisms against aging process.
Our research focuses on the role of ROS and antioxidant system in aging. We are particularly interested in how physical exercise and muscle inactivity modulate progression of aging in skeletal muscle and heart, such as sarcopenia. Our research points to the importance of exercise in regenerating muscle metabolic function and maintaining antioxidant defense so as to keep vitality of the organ during aging.
Related publications
- Ji, L.L and C. Kang. Role of PGC-1α in the Etiology of Sarcopenia. Gerontol. 61: 139-148, 2015.
- Ji, L. L. Redox Signaling in Skeletal Muscle:. Effects of Aging and Exercise Am. J. Physiol. (Adv. Physiol. Edu.) (doi:10.1152/advan.00106.2014.)
- Kang, C., E. Chung, and L. L. Ji. Exercise training stimulates PGC-1 and mitochondrial biogenic pathway in skeletal muscle of aged rats. Exp. Gerontol. 48: 1343-1350, 2013.
- Powers, S.K., L.L. Ji, A.N. Kavazis, and M.J. Jackson. Reactive oxygen species: impact on skeletal muscle. Comprehensive Physiol. 1(2) 941–969, 2011.
- Ji, L. L. , J. R. Dickman, C. Kang, and R. Koenig. Exercise-induced Hormesis may help healthy aging. Dose-Response 28: 73-79, 2010.
- Ji, L. L. Exercise-induced modulation of antioxidant defense. Ann. N.Y. Acad. Sci. 959: 82-92, 2002.