Cell Signaling
Cells communicate with each other via hormones, nerves and chemicals to reach synergistic functions such as growth, differentiation, metabolism, adaptation and self-programmed death (apoptosis). ROS have been found to play an important role in regulating the communications termed redox signaling. Our group has studied several pathways deemed important in the maintenance and adaption of antioxidants , mitochondria, anti-inflammation and aging in muscle and heart, such as PGC-1α, MAP kinase, NFκB, Sirt, and FoxO. We are particularly interested in the effects of exercise, inactivity, aging and nutritional intervention on these signaling pathways. The adaptation of these systems are postulated as a phenomenon called hormesis.